Cardiovascular Engineering encompasses a wide range of biomedical and engineering projects targeted at understanding the mechanisms and treatments of cardiovascular health, disease, and regeneration. Engineering sciences of fluid dynamics and solid mechanics are integrated with biology and diseases of the heart, heart valves, vasculature, and lymphatics with a rapidly growing emphasis on pediatric cardiovascular diseases. This thrust also covers cardiovascular regeneration or repair using up-to-date technologies including stem cells, biomaterials, and nanotechnologies. Biomedical engineers in our department collaborate with practicing clinicians and clinical investigators, biomedical imaging scientists, and basic cardiovascular biologists using experimental and computational approaches asking questions spanning the genes and small molecules to cellular and organ levels that, in most cases are integrative and multi-scale. Fluid dynamics and mechanics of blood are being studied in the heart, heart valves, all major vessels, vascular grafts, and the peripheral vasculature using in vitro, in vivo, multi-scale “OMICS” and in silico approaches, with the latter becoming increasingly prominent. Research associated with mechanical heart valves, new bioprosthetic designs, and polymeric trileaflet valve prostheses is internationally recognized, as is research in arterial hemodynamics, endothelial cell biology, and their roles in atherosclerosis and arterial remodeling. New areas of research include fluid dynamics of thrombosis, aneurysms, and sickle cell disease. Cardiovascular solid mechanics work addresses the mechanical properties and stresses in healthy and diseased arterial cross sections, and examines the role of mechanical factors in the disruption of atherosclerotic plaques. Biomechanical evaluation of the heart failure in adult and pediatric cardiac lesions using swine and ovine models and its translation to clinical use with cardiac MRI is being pursued. Novel technologies that use these biomechanical indices for early detection of disease progression, and to guide therapeutic intervention are in development.