Title

Manoj Bhasin

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Manoj Bhasin
Title/Position
Professor, Director, Genomics, Proteomics, Bioinformatics, and Systems Biology at Children's Healthcare of Atlanta, Co-Director, Atlanta Single-cell Omics and Analytics Initiative (AScOMAI)
Areas of Research

Areas of Research

Biomedical Informatics & Systems Modeling, Cancer Technologies
Contact

Contact

Health Sciences Research Building, Room N320Emory
manoj.bhasin@bme.gatech.edu
404.712.9849
Bhasin Lab
Education

Education

  • Postdoc in Systems Biology, 2006 - Harvard Medical School, Boston, MA USA
  • PhD in Bioinformatics, 2004 - Institute of Microbial Technology/ Jawaharlal Nehru University , INDIA
  • MS in Biochemistry, 2001 - Kurukshetra University, INDIA
Academic Appointments

Academic Appointments

Professor of Pediatrics and Biomedical Informatics
Research Interests

Research Interests

Professor Bhasin’s research program is dedicated to redefining the understanding of complex diseases through the integration of single-cell and spatial genomics with innovative artificial intelligence methodologies. His work focuses on unraveling cellular heterogeneity in cancer and cardio-metabolic diseases, with the goal of identifying previously unrecognized cellular subpopulations, immune dynamics, and metabolic rewiring that drive disease progression and therapeutic resistance. By developing scalable computational frameworks and constructing high-resolution disease atlases, he seeks to bridge molecular discovery with clinical translation—advancing precision diagnostics and next-generation therapeutics to improve patient outcomes.

Publications

Publications

Nature Cancer
1. Pilcher WC, Yao L, Gonzalez-Kozlova E, Pita-Juarez Y, Karagkouni D, Acharya CR, Michaud ME, Hamilton M, Nanda S, Song Y, Sato K, Wang JT, Satpathy S, Ma Y, Schulman J, D'Souza D, Jayasinghe RG, Ohlstrom D, Ferguson KE, Cheloni G, Bakhtiari M, Pabustan N, Nie K, Foltz JA, Saldarriaga I, Alaaeldin R, Lepisto E, Chen R, Fiala MA, Thomas BE, Cook A, Santos JVD, C IL, Figueiredo I, Fortier J, Slade M, Oh ST, Rettig MP, Anderson E, Li Y, Dasari S, Strausbauch MA, Simon VA, Immune Atlas C, Radkevich E, Rahman AH, Chen Z, Lagana A, DiPersio JF, Rosenblatt J, Kim-Schulze S, Lonial S, Kumar S, Bhasin SS, Kourelis T, Dhodapkar MV, Vij R, Avigan D, Cho HJ, Mulligan G, Ding L, Gnjatic S, Vlachos IS, Bhasin M. A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma. Nat Cancer. 2026. Epub 20260109. doi: 10.1038/s43018-025-01072-4. PubMed PMID: 41514053.
Blood Cancer Discovery
2. Ohlstrom DJ, Pilcher WC, Michaud ME, Acharya C, Satpathy S, Gonzalez-Kozlova E, Jayasinghe RG, Ferguson K, Mumme HL, Nanda S, Song Y, Mantrala S, Karagkouni D, Schulman J, Pabustan N, Vieira Dos Santos J, Sherbenou DW, Keats JJ, Gout AM, Foltz S, Lagana A, Kourelis T, Vij R, Dhodapkar MV, Avigan D, Cho HJ, Baughn LB, Nooka AK, Lonial S, Kumar S, Samur MK, Vlachos IS, Ding L, Gnjatic S, Mulligan G, Bhasin MK. Longitudinal profiling of tumor and immune compartments uncovers patterns of dysregulation and associations with response in multiple myeloma. Blood Cancer Discov. 2025. Epub 20251209. doi: 10.1158/2643-3230.BCD-25-0205. PubMed PMID: 41364805.
Nature Communications
Mumme HL, Huang C, Ohlstrom D, Bakhtiari M, Raikar SS, DeRyckere D, Qayed M, Castellino SM, Wechsler DS, Porter CC, Graham DK, Bhasin SS, Bhasin M. Identification of leukemia-enriched signature through the development of a comprehensive pediatric single-cell atlas. Nat Commun. 2025;16(1):4114. Epub 20250502. doi: 10.1038/s41467-025-59362-5. PubMed PMID: 40316535; PMCID: PMC12048633.
Nature Communications
Theocharidis G, Thomas BE, Sarkar D, Mumme HL, Pilcher WJR, Dwivedi B, Sandoval-Schaefer T, Sirbulescu RF, Kafanas A, Mezghani I, Wang P, Lobao A, Vlachos IS, Dash B, Hsia HC, Horsley V, Bhasin SS, Veves A, Bhasin M. Single cell transcriptomic landscape of diabetic foot ulcers. Nat Commun. 2022;13(1):181. Epub 20220110. doi: 10.1038/s41467-021-27801-8. PubMed PMID: 35013299; PMCID: PMC8748704.
Circulation Research
Michaud ME, Mota L, Bakhtiari M, Thomas BE, Tomeo J, Pilcher W, Contreras M, Ferran C, Bhasin SS, Pradhan-Nabzdyk L, LoGerfo FW, Liang P, Bhasin MK. Early Injury Landscape in Vein Harvest by Single-Cell and Spatial Transcriptomics. Circ Res. 2024;135(1):110–34. Epub 20240529. doi: 10.1161/CIRCRESAHA.123.323939. PubMed PMID: 38808504; PMCID: PMC11189745.
Nature Communications
Mumme H, Thomas BE, Bhasin SS, Krishnan U, Dwivedi B, Perumalla P, Sarkar D, Ulukaya GB, Sabnis HS, Park SI, DeRyckere D, Raikar SS, Pauly M, Summers RJ, Castellino SM, Wechsler DS, Porter CC, Graham DK, Bhasin M. Single-cell analysis reveals altered tumor microenvironments of relapse- and remission-associated pediatric acute myeloid leukemia. Nat Commun. 2023;14(1):6209. Epub 20231005. doi: 10.1038/s41467-023-41994-0. PubMed PMID: 37798266; PMCID: PMC10556066.
Genome Medicine
Mumme HL, Raikar SS, Bhasin SS, Thomas BE, Lawrence T, Weinzierl EP, Pang Y, DeRyckere D, Gawad C, Wechsler DS, Porter CC, Castellino SM, Graham DK, Bhasin M. Single-cell RNA sequencing distinctly characterizes the wide heterogeneity in pediatric mixed phenotype acute leukemia. Genome Med. 2023;15(1):83. Epub 20231016. doi: 10.1186/s13073-023-01241-z. PubMed PMID: 37845689; PMCID: PMC10577904.