Title

James Dahlman

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Title/Position
McCamish Foundation Early Career Associate Professor
Areas of Research
Contact

Contact

HSRB-II, Room N620Emory
Biography

Biography

James Dahlman is the McCamish Early Career Professor in the Department of Biomedical Engineering at Georgia Tech and Emory School of Medicine. His lab works at the interface of chemical engineering, genomics, and gene editing by applying big data approaches to nanomedicine. His lab is known for developing DNA barcoded nanoparticles to measure how hundreds of nanoparticles deliver mRNA and siRNA in multiple cell types from a single animal in vivo. The lab uses these approaches to deliver RNA outside the liver.

James was a co-founder and Board Chairman of Guide Therapeutics, which was acquired by Beam Therapeutics. His trainees have become investors, started companies, and work in some of the most cutting-edge organizations in RNA therapeutics. James received his Ph.D. in 2015 from the Harvard-MIT HST Program, where he studied with Robert Langer, and as a post-doc, studied CRISPR-Cas9 with Feng Zhang. 

Research Interests

Research Interests

Professor Dahlman’s research centers on the development of novel gene delivery systems and nanotechnologies for therapeutic applications. His work involves designing nanoparticles to improve nucleic acid delivery efficiency and specificity, with a focus on understanding the interactions between engineered materials and biological systems. The research aims to advance nonviral gene therapies and develop tools for precise manipulation of cellular function in vivo.

Teaching Interests

Teaching Interests

Professor Dahlman’s teaching interests emphasize foundational and advanced topics in biomedical engineering, including molecular and cellular engineering principles, gene delivery technologies, and nanomedicine. His instruction integrates current research to prepare students for interdisciplinary approaches in engineering and medicine. He engages both graduate and undergraduate students in exploring the applications of bioengineering to human health.
Publications

Publications

SN Housley, AR Bourque, LV Matyunina, IA Panicker, ES Echeverri, ..., Tumor agnostic drug delivery with dynamic nanohydrogels, Nature Communications 17 (1), 184, 2026
H Kim, R Zenhausern, K Gentry, L Lian, SG Huayamares, A Radmand, ..., Lipid nanoparticle-mediated mRNA delivery to CD34+ cells in rhesus monkeys, Nature biotechnology 43 (11), 1813-1820, 2025
E Kim, S Johnson, R Zenhausern, S Kapadia, H Kim, J Dahlman, J Woo, Scalable, Antibody-Free Lipid Nanoparticle Achieves Human HSPC-Selective mRNA Delivery In Vivo Without Conditioning, Blood 146, 1067, 2025
K Gentry, L Lian, H Kim, O Celik, C Jones, AR Podilapu, A Shakked, ..., Glycolipid nanoparticles target the spleen and detarget the liver without charge, Proceedings of the National Academy of Sciences 122 (45), e2409569122, 2025
E Michalaki, K Jeong, R Chin, Z Qi, L Liebman, Y González-Vargas, ..., Lipid Nanoparticle Library Screen Reveals Lymphatic Endothelial Cell-Targeting Lipid Nanoparticle for Delivering Vascular Endothelial Growth Factor C mRNA after Lymphatic Injury, ACS nano 19 (48), 40873-40891, 2025
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