Title

Yong Teng

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Headshot
Title/Position
Professor
Contact

Contact

1365-C Clifton Rd NE, Suite C4086, Atlanta, GA 30322Emory
404.712.8514
Education

Education

  • Ph.D. in Molecular Biology, 2007-Sun Yatsen Univeristy
Academic Appointments

Academic Appointments

Professor, Department of Hematology and Medical Oncology
Research Interests

Research Interests

Dr. Teng’s research spans tumor microenvironment, cancer metabolism, and metastasis to dissect tumor-immune crosstalk and to translate mechanistic insights into more effective combination therapeutics. He also possesses extensive expertise in drug discovery, drug delivery, biomedical engineering, bioinformatics, and biomarker research, and is actively engaged in translational oncology clinical trials. 

Publications

Publications

Chen F, Yang F, Popoola DO, Yang J, Tang C, Payne A, Zhang L, Schmitt NC, Xie J, Saba NF, Li Y, Teng Y. Dual CDK and MEK Inhibition potentiates CD8+ T cell-mediated antitumor immunity by inducing pyroptotic cell death in high-mutational head and neck cancer. J Exp Clin Cancer Res. 2025, 44(1):300.

Chen F, Yang J, Popoola DO, Yang F, Liu Y, Wang D, Qin ZS, Chen Z, Saba NF, Chen ZG, Li Y, Teng Y. Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A‐Dependent Fatty Acid Oxidation. Adv Sci. 2025, 12(30):e02146.

Yang J, Chen F, Fu Z, Yang F, Saba NF, Teng Y. Blocking the TCA Cycle in Cancer Cells Potentiates CD36+ T-cell-Mediated Antitumor Immunity by Suppressing ER Stress-Associated THBS2 Signaling. Cancer Res. 2025, 85(11):2014-2026.

Chen F, Lang L, Yang J, Yang F, Tang S, Fu Z, Saba NF, Luo M, Teng Y. SMAC-armed oncolytic virotherapy enhances the anticancer activity of PD1 blockade by including PANoptosis. Biomarker Res. 2025, 13:8.

Yang W, Feng Z, Lai X, Li J, Cao Z, Jiang F, Chen F, Zhan S, Kong F, Yang L, Teng Y, Watford WT, Zhou G, Xie J. Calcium nanoparticles target and activate T cells to enhance anti-tumor function. Nat Commun. 2024, 15(1):10095.

Yang J, Chen F, Lang L, Yang F, Fu Z, Martínez J, Cho A, Saba NF, Teng Y. Therapeutic Targeting of the GLS1-c-Myc Positive Feedback Loop Suppresses Glutaminolysis and Inhibits Progression of Head and Neck Cancer. Cancer Res. 2024, 84(19):3223-3234.

Yang F, Chen F, Shay C, Chen GZ, Saba NF, Teng Y. Distinct Genomic Profiles Reveal Impact of GSTM1 on Racial Survival Disparities in Head and Neck Cancer. J Exp Clin Cancer Res. 2024, 43(1):203.

Saba NF, Chaudhary R, Kirtane K, Marra A, Ekpenyong A, McCook-Veal A, Schmitt NC, Gross JH, Patel MR, Remick J, Bates JE, McDonald MW, Rudra SF, Stokes WA, Biernacki M, Song X, Slebos RJC, Liu Y, Steuer CE, Shin DM, Teng Y, Chung CH. Pembrolizumab and cabozantinib in recurrent and/or metastatic head and neck squamous cell carcinoma (RMHNSCC): long-term survival update with a biomarker analysis. Clin Cancer Res. 2024, 30(20):4601-4608.

Liu Y, Chen S, Wan X, Wang R, Luo H, Chang C, Dai P, Gan Y, Guo Y, Hou Y, Sun Y, Teng Y, Cui X, Liu M. Tryptophan 2,3-dioxygenase-positive matrix fibroblasts fuel breast cancer lung metastasis via kynurenine-mediated ferroptosis resistance of metastatic cells and T cell dysfunction. Cancer Commun (Lond). 2024, 44(11):1261-1286.

Saba NF, Wong SJ, Nasti T, McCook-Veal A, McDonald M, Stokes WA, Anderson A, Ekpenyong A, Rupji M, Abousaud M, Rudra S, Bates J, Remick JS, Joshi NP, Woody NM, Awan M, Geiger JL, Shreenivas A, Samsa J, Ward MC, Schmitt NC, Patel M, Higgins K, Teng Y, Steuer CE, Shin DM, Liu Y, Ahmed R, Koyfman SA. Intensity Modulated Re-Irradiation with Concurrent and Adjuvant Nivolumab in Recurrent or Second Primary Head and Neck Squamous Cell Carcinoma: A Nonrandomized Controlled Trial. JAMA Oncol. 2024, 10(7):896-904.

Chen F, Tang C, Yang F, Ekpenyong A, Qin R, Xie J, Momen-Heravi F, Saba NF, Teng Y. HSP90 inhibition suppresses tumor glycolytic flux to potentiate the therapeutic efficacy of radiotherapy for head and neck cancer. Sci Ad. 2024, 10: eadk3663.

Cao Z, Yang X, Yang W, Chen F, Jiang W, Zhan S, Jiang F, Li J, Ye C, Lang L, Zhang S, Feng Z, Lai X, Liu Y, Mao L, Cai H, Teng Y, Xie J. Modulation of Dendritic Cell Function via Nanoparticle-Induced Cytosolic Calcium Changes. ACS Nano. 2024, 18(10):7618-7632.

Lee H, Lee TJ, Galloway CA, Zhi W, Xiao W, de Mesy Bentley KL, Sharma A, Teng Y, Sesaki H, Yoon Y. The mitochondrial fusion protein OPA1 is dispensable in the liver and its absence induces mitohormesis to protect liver from drug-induced injury. Nat Commun. 2023, 14(1):6721.

Saba NF, Steuer CE, Ekpenyong A, McCook-Veal A, Magliocca K, Patel M, Schmitt NC, Stokes W, Bates JE, Rudra S, Remick J, McDonald M, Abousaud M, Tan AC, Fadlullah MZH, Chaudhary R, Muzaffar J, Kirtane K, Liu Y, Chen GZ, Shin DM, Teng Y, Chung CH. Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial. Nat Med. 2023, 29(4):880-887.