Title

Steven H. Liang

(he/him)
Headshot Placeholder
steven liang
Title/Position
Professor, Radiology and Biomedical Engineering;, Director, Emory Positron Emission Tomography (PET) Imaging Center, Endowed Director of Radiochemistry, Cyclotron Facility and Radiopharmacy
Contact

Contact

HSRB2, G200Emory
4047127641
Biography

Biography

Steven H. Liang began his professional career as a NSERC fellow under the mentorship of Professor EJ Corey at Harvard University in 2010. He started his junior faculty position (Assistant Professor 2013) at Massachusetts General Hospital and Harvard Medical School, then promoted to the Director of Radiochemistry (2017) and Associate Professor of Radiology (2019). In early 2022, Dr. Liang assumed the role of the inaugural head at the newly established Translational PET Center at Emory University and Endowed Directorship of Radiochemistry Program. He joined the Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology in 2024 as a PhD Program Faculty. As PI on numerous foundation- and federal-funded research projects, Dr. Liang has created an efficient research team to lead the projects and collaborated with stellar scientists in the world. This effort has resulted in >280 publications and more than 20 national and international awards and recognitions. Dr. Liang’s research interests encompass the discovery and translation of molecular imaging probes and radioactive drug discovery, including novel radiochemistry, PET imaging diagnostics and radioligand therapy, as well as the translation of these technologies into clinical settings (Phase I first-in-human studies; Phase II efficacy/target engagement validation, and PET imaging based observational human trials).

Education

Education

  • NSERC Fellow, Harvard University, 2012
  • PhD, University of British Columbia, 2010
  • BSc, Tianjin University, 2003
Academic Appointments

Academic Appointments

Professor of Radiology & Imaging Sciences and Biomedical Engineering
Affiliated Centers & Institutes

Affiliated Centers & Institutes

Teaching Interests

Teaching Interests

Molecular Imaging, Biomedical Imaging, Chemistry and Pharmacology
Publications

Publications

Rong, J., Haider, A., Jeppesen, T. E., Josephson, L. & Liang, S. H. “Radiochemistry for Positron Emission Tomography”, Nature Communications, 2023, 14, 3257.
Rotstein, B. H.; Stephenson, N. A.; Vasdev, N. & Liang, S. H. “Spirocyclic hypervalent iodine(III)-mediated radiofluorination of non-activated and hindered aromatics”, Nature Communications, 2014, 5, 4365.
Liang, S. H., Wang, L., Stephenson, N. A., Rotstein, B. H., and Vasdev, N. “Facile 18F Labeling of Non-activated Arenes via a Spirocyclic Iodonium(III) Ylide Method and its Application in the Synthesis of the mGluR5 PET Radiopharmaceutical [18F]FPEB”, Nature Protocol, 2019, 14, 1530-1545.
Haider, A., Zhao, C., Wang, L., Xiao, Z., Rong, J., Xia, X., Chen, Z., Pfister, S. K., Mast, N., Yutuc, E., Chen, J., Li, Y., Shao, T., Warnock, G. I., Dawoud, A., Connors, T. R., Oakley, D.H., Wei, H., Wang, J., Zheng, Z., Xu, H., Davenport, A. T., Daunais, J. B., Van, R. S., Shao, Y., Wang, Y., Zhang, M. R., Gebhard, C., Pikuleva, I., Levey, A. I., Griffiths, W.J. and Liang, S. H. “Assessment of cholesterol homeostasis in the living human brain”, Science Translational Medicine, 2022, 14, eadc9967.
Chen, Z.; Chen, J.; Wakana, M.; Yi, Y.; Rong, J.; Li, Y.; Leon, C. E.; Shao, T.; Song, Z.; Yamasaki, T.; Zhang, Y.; Josephson, L.; Van, R. S.; Shao, Y.; Zhang, M-R. and Liang, S. H. “Preclinical evaluation of novel positron emission tomography (PET) probes for imaging leucine-rich repeat kinase 2 (LRRK2)”, Journal of Medicinal Chemistry, 2024, 67, 2559-2569
Rong, J.; Zhao, C.; Chaudhary, A. F.; Ware, T.; Van, R. S.; Li, Y.; Leon, E. R. C.; Dang, V.; Chen, J.; Xiao, Z.; Zhou, X.; Zhang, W.; Bi, C.; Zhang, K.; Patel, J. S.; Shao, Y.; Ran, C.; Collin, L.; Haider, A.; Cravatt, B. F. and Liang, S. H. “Development of a novel 18F-labeled reversiblebinding radioligand for imaging monoacylglycerol lipase with positron emission tomography“, Acta Pharmaceutica Sinica B, 2025, 15, 6714-6726.
Zhou, X.; Chen, J.; Patel, J. S.; Ran, W.; Li, Y.; Van, R. S.; Ibrahim, M. M. H.; Zhao, C.; Gao, Y.; Rong, J.; Chaudhary, A. F.; Li, G.; Hu, J.; Davenport, A. T.; Daunais, J. B.; Shao, Y.; Ran, C.; Collier, T. L.; Haider, A.; Schuster, D. M.; Levey, A.; Wang, L.; Corfas, G.; Liang, S. H. “Imaging poly(ADP-ribose) polymerase-1 (PARP1) in vivo with 18F-labeled brain penetrant positron emission tomography (PET) ligand”, Acta Pharmaceutica Sinica B, 2025, 15, 10, 5036-5049.
Song, Z.; Li, Y.; Dahl, K.; Sun, Z.; Chen, J.; Zhou, X.; Gao, Y.; Rong, J.; Zhao, C.; Yuan, K.; Chaudhary, A. F.; Patel, J. S.; Collier, T. L.; Ran, C.; Muehlfenzl, K. S.; Haider, A.; Elmore, C. S.; Schou, M. and Liang, S. H. “Development and Preclinical Characterization of [18F]H3-2406 and [18F]H3-2407 for Positron Emission Tomography Imaging of the Histamine Subtype-3 Receptor”, Journal of Medicinal Chemistry, 2025, 68, 15, 15372–15385.