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Breathtaking Breakthrough: Lung-on-a-Chip Defends Itself

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The tool mimics real lung behavior and could transform disease research and treatment.
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Sep 24, 2025 | By Georgia Tech Research
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Photo of Ankur Singh (left) and Rachel Ringquist (right) pointing to the microscopic lung-on-a-chip that has a built-in immune system.
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Ankur Singh and Rachel Ringquist point to the microscopic lung-on-a-chip that has a built-in immune system. (Photo by Georgia Tech Research)
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In a stunning leap forward for biomedical engineering, Georgia Tech and Vanderbilt researchers have developed the first lung-on-a-chip with a functioning immune system — a miniature, living model that mimics how real lungs breathe, fight disease, and heal. This innovation allows scientists to observe immune responses in real time, potentially revolutionizing how we study respiratory illnesses and test treatments. The chip, soft and pliable like a gummy bear, could pave the way for more accurate disease models and reduce reliance on animal testing.

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