Title

Edward Botchwey

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Title/Position
Professor
Areas of Research

Areas of Research

Biomaterials & Regenerative Technologies, Immunoengineering
Contact

Contact

IBB 2311Georgia Tech
edward.botchwey@bme.gatech.edu
404.385.5058
Botchwey Laboratory
Education

Education

  • Ph.D. in Bioengineering, 2002 — University of Pennsylvania
  • M.S.E. in Materials Science and Engineering, 1999 — University of Pennsylvania
  • B.S. in Mathematics, 1993 — University of Maryland at College Park
Research Interests

Research Interests

Dr. Botchwey's research investigates how bioactive lipid signaling — particularly sphingolipid and pro-resolving mediator pathways — can be harnessed through engineered biomaterials to reprogram immune responses and promote tissue regeneration. His laboratory has demonstrated that targeted modulation of sphingosine-1-phosphate receptors and local delivery of resolution-phase lipids from synthetic scaffolds recruits pro-regenerative immune cell subsets, resolves pathological inflammation, and restores function across musculoskeletal, craniofacial, and vascular injury models. Current work extends this immunoregenerative framework toward programmable extracellular vesicle therapeutics and scalable cell manufacturing, positioning lipid-mediated immune engineering as a translational bridge between fundamental immunobiology and next-generation regenerative medicine.

Teaching Interests

Teaching Interests

Dr. Botchwey teaches undergraduate and graduate courses in biomaterials and conservation principles in biomedical engineering, emphasizing quantitative reasoning grounded in real-world clinical and translational contexts. His teaching integrates current research on immune-engineered biomaterials and lipid signaling into the classroom, connecting students to active frontiers in regenerative medicine and cell manufacturing. He is committed to mentoring the next generation of biomedical engineers and has directed graduate training programs — including the NIH-funded Cell and Tissue Engineering Training Program — that prepare trainees to work at the intersection of immunology, materials science, and translational biotechnology.
Publications

Publications

Awojoodu AO, Ogle ME, Sefcik LS, Bowers DT, Martin K, Brayman KL, Lynch KR, Peirce-Cottler SM, Botchwey EA. Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis. Proc Natl Acad Sci U S A 110(34) (2013) 13785-9
Sok MCP, Baker N, McClain C, Lim HS, Turner T, Hymel L, Ogle M, Olingy C, Palacios JI, Garcia JR, Srithar K, García AJ, Qiu P, Botchwey EA. Dual delivery of IL-10 and AT-RvD1 from PEG hydrogels polarize immune cells towards pro-regenerative phenotypes. Biomaterials 268 (2021) 120475
Shah DC, DeVeaux SA, Zhang H, Liu AY, Adedipe TA, Chiappa NF, Patel KA, Jang YC, Goudy SL, Sulchek T, Roy K, Botchwey EA. Exogenous delivery of sphingomyelinase mediates mesenchymal stromal cell-extracellular vesicle biogenesis, alters cargo sorting, and therapeutic potency in vitro. iScience (In Press, 2025)
Hatoum L, Song H, Alexander D, Omojola VO, Moore H, Frank JN, Botchwey EA, Platt MO. Bone marrow transplant protects mice from sickle cell-mediated large artery remodeling. Sci Transl Med 17 (2025)
Toma AI, Shah D, Roth D, Piña JO, Hymel L, Turner T, Kamalakar A, Liu K, Bartsch P III, Jacobs L, D'Souza R, Liotta D, Botchwey EA, Willett NJ, Goudy SL. Accelerating oral wound healing using bilayer biomaterial delivery of FTY720 immunotherapy. Adv Healthc Mater 13(30) (2024) e240148
Media

Media