Title

Laura Hansen

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Title/Position
Assosciate Professor
Contact

Contact

HSRB II, Office N242Emory
404.712.2342
Biography

Biography

Dr. Laura Hansen is an Associate Professor in the Department of Medicine, Division of Cardiology at Emory University School of Medicine. She received her BS in Bioengineering from the University of Pittsburgh in 2007 and PhD in Bioengineering from the Georgia Institute of Technology in 2012 where she studied the mechanics of blood vessel walls and changes associated with different disease states. She then completed her post-doctoral fellowship studying the RAGE receptor in peripheral artery disease at Emory University in Cardiology. She is program faculty in Biomedical Engineering and Molecular and Systems Pharmacology graduate programs and Associate Program Director for the Cardiovascular Research Scientist Pathway in the Cardiology Fellowship program. 

Education

Education

  • Ph.D. in Bioengineering, 2012- Georgia Institute of Technology
  • B.S. in BioEngineering, 2007- University of Pittsburgh
Academic Appointments

Academic Appointments

Division of Cardiology, Department of Medicine, Emory University
Research Interests

Research Interests

Dr. Hansen’s lab studies the interactions between satellite cells and the vasculature. Satellite cells are skeletal muscle progenitor cells that are known to play an important role in muscle repair after injury and adaptation to exercise. However, the Hansen lab focuses on a previously underexplored role of satellite cells in vascular growth. They have found that satellite cells, when activated, produced a number of chemoattractant growth factors that drive the migration of vascular smooth muscle and endothelial cells which in an important factor in the growth and development of blood vessels. This area is of particular interest in the context of peripheral artery disease, where patients suffer from ischemic tissue damage but treatment options are still limited. The lab has shown that ischemia stimulates satellite cells and are exploring ways to harness their angiogenic properties in vivo or through therapeutically delivered cells.

Teaching Interests

Teaching Interests

Dr. Hansen teaches cardiovascular physiology and pathophysiology at the graduate level. She also mentors undergraduate and graduate students and postdoctoral fellows.
Publications

Publications

Oh DG, Hansen L, Taylor WR, “Is current Laser Doppler Perfusion Imaging (LDPI) in Hind limb Ischemia (HLI) truly a "gold standard" for Preclinical Peripheral Artery Disease (PAD) research”, JACC: Basic to Translational Science, 2025 Jan, 10 (1) 104–106.
Lewis C, Sellak H, Hansen L, Joseph G, Hurtado J, Archer D, Jun H, Brown LA, and Taylor WR. “Increasing Nitric Oxide Bioavailability Fails to Improve Collateral Vessel Formation in Humanized Sickle Cell Mice” Laboratory Investigation, 2022, 102(8):805-813.
Hansen L, Joseph G, Valdivia A, Taylor WR. “RAGE Expression in Satellite Cells Modulates their Angiogenic Effects” , Journal of the American Heart Association. 2021;10(21):e022127.
S Mavris and L Hansen, “Optimization of Oxygen Delivery and Diffusion within Hydrogels”, Journal of Biomechanics, 2021, 143(10):101004.
M Sayegh, K Cooney, W Han, L Want, E Shin, F Strobel, L Hansen, A Garcia, and R Levit “A Hydrogel Strategy to Augment Tissue Adenosine to Improve Hindlimb Perfusion,” ATVB, 2021, 41(6):e314-e324.
Mohiuddin M, Lee NH, Moon J, Han WM, Anderson S, Choi J, Nakhai S, Tran T, Aliya B, Kim D, Gerold A, Hansen L, Taylor WR, Jang YC. “Critical Limb Ischemia Induces Remodeling of Skeletal Muscle Motor Unit and Myonuclear- and Mitochondrial-Domains” Scientific Reports, 2019, 9(1):95551.
Breed E, Hilliard C, Yoseph B, Mittal R, Liang Z, Chen CW, Burd E, Brewster L, Hansen L, Gleason RL, Pandita T, Ford M, Hunt C, Coopersmith G, “The small heat shock protein HSPB1 protects mice from sepsis.” Scientific Reports, 2018, 8(1):12493.
Okwan-Duodu D, Hansen L, Joseph G, Lyle A, Weiss D, Archer D, & Taylor WR. “Impaired Post-ischemic Neovascularization in Sickle Cell Disease.” Atherosclerosis, Thrombosis, and Vascular Biology, 2018, 38(5):1125-1133.
Hansen L, Gupta D, Joseph G, Weiss D, & Taylor WR, “The receptor for advanced glycation end products impairs collateral formation in both diabetic and non-diabetic mice.” Laboratory Investigation, 2016, 97(1):34-42.
Hansen L, and Taylor WR, “Is arterial stiffness a cause or consequence of atherosclerosis?” Atherosclerosis. 2016, 249: 226-227.