Title

Cassie S. Mitchell

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Title/Position
Associate Professor
Biography

Biography

Cassie S. Mitchell, Ph.D., is an Associate Professor of Biomedical Engineering at Georgia Tech and Emory University. She directs the Laboratory for Pathology Dynamics, where her team advances interpretable artificial intelligence and machine learning to understand complex and neurodegenerative disease. By integrating knowledge graphs, multimodal biomedical data, and dynamic modeling, she develops scalable computational frameworks that bridge engineering, computation, and clinical science. She is also affiliated with Georgia Tech’s programs in Machine Learning and Computational Science & Engineering. A four-time Paralympian and Team USA medalist, she brings leadership and advocacy experience to her academic and public engagement efforts.

Education

Education

  • Ph.D. in Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine
  • B.S. in Chemical Engineering, Oklahoma State University
Research Interests

Research Interests

My research focuses on developing interpretable artificial intelligence and machine learning frameworks to model complex disease as dynamic, interconnected systems. Rather than treating disease as static diagnostic categories, my lab integrates knowledge graphs, biomedical natural language processing, multimodal data, and systems engineering principles to uncover mechanisms of disease progression and therapeutic response.

While much of this work centers on multifactorial and neurodegenerative disease, the underlying methods are designed to be generalizable across heterogeneous biomedical domains and scalable to diverse clinical contexts. By bridging literature-scale discovery with patient-level data, we build scalable, reproducible computational architectures that advance predictive and translational medicine.

Teaching Interests

Teaching Interests

My teaching interests span neurology, neuroscience, machine learning, and data science within a biomedical engineering framework. I am particularly interested in training students to think across scales—from molecular mechanisms to systems-level disease modeling—and to apply quantitative methods to real-world clinical and translational problems.

Through courses such as Clinical Neurology, Translational Neuroengineering, and Bioengineering Statistics, I emphasize foundational engineering principles, statistical reasoning, and interpretable machine learning as tools for understanding complex disease. I am committed to equipping students with both technical depth and translational insight, preparing them to bridge engineering, computation, and clinical science.
Publications

Publications

Tandon R, Zhao L, Watson CM, Sarkar N, Elmor M, Heilman C, Sanders K, Hales CM, Yang H, Loring DW, Goldstein FC, Hanfelt JJ, Duong DM, Johnson ECB, Wingo AP, Wingo TS, Roberts BR, Seyfried NT, Levey AI, Lah JJ, Mitchell CS. Stratifying risk of Alzheimer's disease in healthy middle-aged individuals with machine learning. Brain Commun. 2025 Mar 25;7(2):fcaf121. doi: 10.1093/braincomms/fcaf121. PMID: 40226382; PMCID: PMC11986205.
Kartchner, D., Deng, J., Lohiya, S., Kopparthi, T., Bathala, P., Domingo-Fernández, D., and Mitchell, C.S. 2023. A Comprehensive Evaluation of Biomedical Entity Linking Models. In Proceedings of the 2023 Conference on Empirical Methods in Natural Language Processing, pages 14462–14478, Singapore. Association for Computational Linguistics.
Sedler AR, Mitchell CS. SemNet: Using Local Features to Navigate the Biomedical Concept Graph. Front Bioeng Biotechnol. 2019 Jul 3;7:156. doi: 10.3389/fbioe.2019.00156. PMID: 31334227; PMCID: PMC6616276.
Lee AJB, Bi S, Ridgeway E, Al-Hussaini I, Deshpande S, Krueger A, Khatri A, Tsui D, Deng J, Mitchell CS. Restoring Homeostasis: Treating Amyotrophic Lateral Sclerosis by Resolving Dynamic Regulatory Instability. Int J Mol Sci. 2025 Jan 21;26(3):872. doi: 10.3390/ijms26030872. PMID: 39940644; PMCID: PMC11817447.
Iyer MR, Zhao B, He X, Camacho D, Wei Z, Deng J, Mitchell CS. An Artificial Intelligence-Driven Multimorbidity Framework Reveals a Shared Metabolic and Immune Core Across Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia. Biomedicines. 2026; 14(2):444. https://doi.org/10.3390/biomedicines14020444
Media

Media