Menu
Close
Shuichi Takayama
Shuichi-Takayama's picture
Shuichi Takayama
Professor
GRA Eminent Scholar
Price Gilbert, Jr. Chair in Regenerative Engineering and Medicine
EBB 4018
404.385.5722
Research Interests:

Microfluidic models of cancer metastasis, Lung-on-a-chip, Biomarker analysis, Chromatin as epigenetic and immune material, Nanofluidics, Bacteria & Microbiome.

Research interests include use of micro/nanofluidics for cell analysis, diagnostics, and chromatin analysis. Specific research topics include high throughput 3D cell cultures, organs-on-a-chip construction and design, the role of rhythm in cell signaling, self-switching fluidic circuit design, fracture fabrication, and microscale liquid-liquid phase separation.

We work on organs-on-a-chip systems of the lung, intestine, cancer, adipocytes, and other tissues. We have also developed therapeutic microfluidic systems for treatment of infertility. As we worked with these systems, we realized the critical needs to incorporate the immune system and to facilitate biochemical analysis of cellular responses using small volumes of liquid available from the organs-on-a-chip. For this purpose, we have developed neutrophil extracellular trap (NETs) inspired inflammatory biomaterials. We have also developed aqueous two phase system (ATPS) droplet arrays that allow convenient, reliable, and high throughput immunoassays of cytokines. The ATPS technology is also useful for cellular bioprinting. One of the advantages of microfluidic cell cultures, compared to conventional static cell culture, is the ability to perform biorhythmic cell stimulation. We have significant interest in combining microfluidics, live cell imaging, and computational modeling to dissect signaling pathway architectures and better control cellular function. Working with small numbers of cells, we also realized there was a need for single cell, single fiber epigenetic analysis. Towards this goal, we are developing nanofluidic devices to linearize single chromatin fibers and perform high-resolution histone modification mapping.

Publications:
  

Map of Coulter Department of Biomedical Engineering at Georgia Tech and Emory University

BME @ Emory

Coulter Department of Biomedical Engineering
Georgia Institute of Technology &
Emory University School of Medicine

BME @ GT:
313 Ferst Drive, Room 2127 Atlanta, GA 30332
Phone: 404.385.0124 :: Fax: 404.894.4243

TEP @ GT:
387 Technology Circle NW Atlanta, GA 30313
Phone: 404.385.0124 :: Fax: 404.894.4243

BME @ Emory:
1760 Haygood Dr, Ste W 200 Atlanta, GA
30322-4250
Phone: 404.727.9874 :: Fax: 404.727.9873