Title

Simone A Douglas-Green

(she/her)
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Photo of Simone Douglas-Green
Title/Position
Assistant Professor
Areas of Research

Areas of Research

Biomaterials & Regenerative Technologies, Biomedical Informatics & Systems Modeling, Cardiovascular Engineering
Contact

Contact

Whitaker 2113Georgia Tech
simone.douglas-green@bme.gatech.edu
404-894-1134
Douglas-Green Lab
Education

Education

  • B.S., Biomedical Engineering, University of Miami
  • Ph.D. in Biomedical Engineering, Georgia Tech & Emory University
  • Postdoctoral Fellowship, Massachusetts Institute of Technology
Research Interests

Research Interests

The Douglas-Green Lab uses a team-based and interdisciplinary approach to study mechanisms of bio-nano interactions and improve fundamental knowledge of how nanoparticles interact with biological environments. Our work focuses on understanding nanocarrier interactions within biological environments, with a particular interest in characterizing nanoparticle-protein complexes or protein/biomolecular coronas that form on nanoparticle surfaces. These bio-nano interactions drive our research goals in the lab: (1) develop tools/techniques to study how biology interacts with nanoparticles with an emphasis on (2) understanding person and disease specific proteins coronas, and (3) improving therapeutic potential and leverage proteins as biomarkers for early disease detection.
 

Teaching Interests

Teaching Interests

Dr. Douglas-Green currently teaches courses in introductory design and problem solving, and also mentors undergradaute and graduate level students in her lab. Her goal is to train the next generation of engineers to be “EPIC”- engineering with purpose, intentionality, and compassion. Being “EPIC” means thinking intentionally about the impact that our work has on different communities, and acknowledging the influence we have on society through the engineering problems and biological questions we choose to pursue.
Publications

Publications

Cationic Dendrimer Nanoformulation Improves Therapeutic Efficacy of Pro-Anaboli…
Park JH, Johnston BM, Simone A. Douglas-Green, Strom ZD, Grodzinsky AJ, Hammond PT. “Cationic Dendrimer Nanoformulation Improves Therapeutic Efficacy of Pro-Anabolic and Anti-Catabolic Therapeutics in Osteoarthritis”. Regen. Eng. Transl. Med. (2026). https://doi.org/10.1007/s40883-025-00518-6
Layer-by-Layer Nanoparticle Outer Polyion Impacts Protein Corona Formation
Dacoba TG*, Simone A. Douglas-Green*, Murthy B, Restrepo AD, Strom Z, Billingsley M, Pryor M, Hammond PT. “Layer-by-Layer Nanoparticle Outer Polyion Impacts Protein Corona Formation”. BioRxiv. 2025.08.13. https://doi.org/10.1101/2025.08.13.670086
*authors contributed equally to this work, by alphabetical order
Investigating Bio-Nano Interactions of PEGylated Cationic Polyamidoamine (PAMAM…
Simone A. Douglas-Green, Aleman JA, Dampty VM, Murthy B, Johnston BM, Ho Park J, Grodzinsky AJ, Hammond PT. “Investigating Bio-Nano Interactions of PEGylated Cationic Polyamidoamine (PAMAM) Dendrimers within Synovial Joints.” BioRxiv. 2025.08.12. https://doi.org/10.1101/2025.08.09.668990
Electrophoresis-Based Approach for Characterizing Dendrimer-Protein Interaction…
Simone A. Douglas-Green, Aleman, J. A., & Hammond, P. T. “Electrophoresis-Based Approach for Characterizing Dendrimer-Protein Interactions: A Proof-of-Concept Study”. ACS Biomaterials Science and Engineering. 2024 10(6), 3747–3758.
Cysteine cathepsins are altered by flow and fibroblasts within an in vitro micr…
Simone A. Douglas, Haase K, Kamm RD, Platt MO. "Cysteine cathepsins are altered by flow and fibroblasts within an in vitro microvascular niche" APL Bioeng. 2020; 4(4):046102
Human cathepsins K, L, and S: Related proteases by unique fibrinolytic activity
Simone A. Douglas, LaMonthe SE, Singleton TS, Averett RD, Platt MO. “Human cathepsins K, L, and S: Related proteases by unique fibrinolytic activity”. Biochimica et Biophysica Acta. 2018 Sep; 1862(9)1925-1932

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