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DNA

James Dahlman
DNA: Faster Data, More Storage, Better Drugs

Georgia Tech researcher James Dahlman pens essay for Scientific American as new DNA barcoding company continues to grow
Cells, stained in green with blue nuclei, are targeted by nanoparticles carrying DNA barcodes (white). The nanoparticles efficiently delivery their DNA payload into the cells. (Image courtesy of Daryll A. Vanover, Kalina Paunovska, and Cory Sago at Georgia Tech).
Comparison Shows Value of DNA Barcoding in Selecting Nanoparticles

New research may guide selection of nanoparticles for transporting therapeutic molecules into cells.
Nature inspired this synthetic microweb that nabs bacteria and allows antibiotics to more effectively kill them. White blood cells shoot so-called NETs like Spiderman at bacteria. NETs contain hundreds of ingredients, the main one being DNA, but researchers engineered their microweb with just DNA and one other ingredient. Credit: Georgia Tech / Ella Maru Studio (work for hire)
Snaring Bacteria in DNA-based Nets the Way White Blood Cells Do

Like Spiderman, white bloods cells shoot NETs at bacteria, made mostly of DNA, and this synthetic microweb emulates it.
James Dahlman, an assistant professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, holds a microfluidic chip used to fabricate nanoparticles that could be used to deliver therapeutic genes. (Credit: Rob Felt, Georgia Tech)
Red Glow Helps Identify Nanoparticles for Delivering RNA Therapies

A new screening process could dramatically accelerate the identification of nanoparticles suitable for delivering therapeutic RNA into living cells.
Close-up image shows a microfluidic chip used to fabricate nanoparticles that could be used to deliver therapeutic genes to specific organs of the body. Colored liquids have been added to highlight the channels. (Credit: Rob Felt, Georgia Tech)
DNA “Barcoding” Allows Rapid Testing of Nanoparticles for Therapeutic Delivery

Researchers have developed a new technique for rapidly screening the ability of nanoparticles to selectively deliver therapeutic genes to specific organs of the body.
Atomic force microscopy image of structures formed by the the self-assembly of TAP-ribose nucleoside with cyanuric acid. Credit: Nicholas Hud.
New Study Brings Scientists Closer to the Origin of RNA

New research shows one way that a molecule leading to RNA might have first formed.