The Thomas laboratory studies the role of fluid transport phenomena in regulating the dynamics and kinetics of cellular and molecular transport processes. The rationale for this work is that it will provide novel design principles for targeted drug delivery strategies in disease therapy. Specifically, we integrate cellular engineering, biochemistry, biomaterials, and immunology fundamentals to 1) elucidate how physical forces regulate seemingly unrelated aspects of cancer such as metastasis and immune suppression as well as 2) develop novel immunotherapeutics to treat immune-regulated diseases such as cancer using biomaterials engineering.