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Melissa Kemp
Melissa-Kemp's picture
Melissa Kemp
Associate Professor
Georgia Cancer Coalition Distinguished Cancer Scholar
EBB 3019
404.385.6341
Research Interests:

Systems biology, computational modeling, redox metabolism and signal tranduction

The Kemp lab is focused on understanding how metabolism influences the decisions that cells make. Aging, stem cell differentiation, cancer metastasis, and inflammation rely on progressive changes in metabolism resulting in increased levels of reactive oxygen species. Collectively, the accumulation of these molecules is known as cellular oxidation, and pathological levels are referred to as oxidative stress. Our lab develops systems biology tools for investigating how cellular oxidation influences cellular fate and interpretation of cues from the extracellular environment. We are interested in the collective behavior that arises during stem cell differentiation, immune cell responses, or drug treatments from metabolic diversity in individual cells. Because of the numerous biochemical reactions involved, we develop computational models and analytical approaches to understand how complex protein network properties are influenced by redox-sensitive proteins; these proteins typically have reactive thiol groups that are post-translationally regulated in the presence of reactive oxygen species to alter activity and/or function. Experimentally, we develop novel high-throughput single cell techniques for the detection and quantification of intracellular oxidation.

Publications:
  

Map of Coulter Department of Biomedical Engineering at Georgia Tech and Emory University

BME @ Emory

Coulter Department of Biomedical Engineering
Georgia Institute of Technology &
Emory University School of Medicine

BME @ GT:
313 Ferst Drive, Room 2127 Atlanta, GA 30332
Phone: 404.385.0124 :: Fax: 404.894.4243

TEP @ GT:
387 Technology Circle NW Atlanta, GA 30313
Phone: 404.385.0124 :: Fax: 404.894.4243

BME @ Emory:
1760 Haygood Dr, Ste W 200 Atlanta, GA
30322-4250
Phone: 404.727.9874 :: Fax: 404.727.9873