Dr. Bhasin's laboratory has developed strategies for analysis of transcriptome, epigenome, and proteomics data to perform multi-scale modeling of interaction among different cells molecular level and to identify novel biomarkers. He and his team are currently focusing on developing novel single-cell omics approaches to understand disease heterogeneity and the impact of treatments at single-cell resolution. He is involved in developing approaches for the analysis of multi-dimensional single-cell data by developing innovative approaches for single-cell sparsity, batch correction, annotation, and integration. Using these approaches, his group is working toward understanding: 1. Understanding heterogeneity and relapse mechanisms in pediatric hematological malignancies 2. Understanding heterogeneity and progression in multiple myeloma. 3. Development of molecular diagnostics platforms for cancer diagnosis and prognosis 4. Identification of biomarkers for early detection of pancreatic cancer, glioblastoma, and colon cancer 5. Artificial intelligence-based histopathology and radiology cancer image analysis approaches 6. Single-cell Atlas for Pediatric Cancers Additionally, our group is also developing Biomarkers associated with impaired healing of Diabetic Foot Ulcers using single-cell profiling and deep learning-driven wound image analysis. We are working collaboratively to develop innovative genomics and clinical data-driven drug repurposing approaches.
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