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Dong Moon Shin
Dong Moon Shin
M.D., F.A.C.P., Professor
Winship Cancer Institute C30094
404.778.5990
Research Interests:

Hematology, Medical Oncology

Dr. Shin’s research initially focused on demonstrating the phenomenon of field cancerization and the multistep carcinogenesis process using animal models and analyzing tissue samples from different sites in the aerodigestive tract and premalignant lesions of patients with head and neck cancer. Dr. Shin investigated the chemopreventive efficiency of retinoids in head and neck cancer in preclinical and clinical settings.  These compounds, in particular, 13-cRA demonstrated early promise in several prospective double blind, placebo-controlled randomized trials in reversing oral premalignancy and preventing second primary tumors. The long term follow-up of these studies showed only a marginal protective effect, and the use of high doses of 13-cRA was limited by toxicity.  To overcome retinoid resistance in the chemopreventive setting, Dr. Shin and his colleagues initiated a combination of 13-cRA, interferon-α, and α-tocopherol in advanced premalignant lesions and in bioadjuvant therapy for advanced head and neck cancer.  The results of these studies were highly promising and drew considerable national attention from head and neck cancer researchers. Currently Dr. Shin is continuously focused on biomarker-driven preclinical and clinical chemopreventive studies using synthetic compounds (i.e., EGFR-TKIs, COX inhibitors) and natural compounds, such as green tea polyphenons, luteolin, resveratrol, curcumin and others. Dr. Shin has also focused on anticancer drug delivery using nanotechnology in collaboration with other investigators. Some of the compounds explored will be taken into clinical trials.

Publications:
  

Map of Coulter Department of Biomedical Engineering at Georgia Tech and Emory University

BME @ Emory

Coulter Department of Biomedical Engineering
Georgia Institute of Technology &
Emory University School of Medicine

BME @ GT:
313 Ferst Drive, Room 2127 Atlanta, GA 30332
Phone: 404.385.0124 :: Fax: 404.894.4243

TEP @ GT:
387 Technology Circle NW Atlanta, GA 30313
Phone: 404.385.0124 :: Fax: 404.894.4243

BME @ Emory:
1760 Haygood Dr, Ste W 200 Atlanta, GA
30322-4250
Phone: 404.727.9874 :: Fax: 404.727.9873